Applied BioSystem >>

Professional Accomplishments:

Published articles demonstrating integration and copy number variation of T-DNA in plants at University of Washington.

Developed, published and patented novel T-DNA expression vector for plant cell transformation at Stauffer Chemical Co.

Led research group that published articles on the nucleotide sequence and genome organization of Maize Chlorotic Mottle Virus at Oklahoma State University.

Research Director for plant gene expression research and isolation of genes for crop improvement at Pioneer Hi-Bred.

Applications Manager for genetic analysis products and applications at Applied Biosystems.

Applications Manager for High Throughput Discovery sequencing system at Applied Biosystems.

Presentation Outline:
The decreasing cost of sequencing is driving the development of genome-wide applications based on sequence data. Instead of needing different platforms for applications such as gene expression, genotyping and sequencing, it is becoming possible to use sequencing as the universal currency for most, if not all, genetic analysis. The SOLiD(tm) System is a ligation-based, massively parallel sequencing system that can currently generate in excess of 1 Gb of DNA sequence per run. Investigators can elect to use either fragment or mate-paired libraries and can run one or multiple samples at a time. We are taking advantage of the high throughput and system flexibility of the SOLiD(tm) system to collaborate with a number of scientific groups to develop a range of applications. An update on application development and examples of the data generated will be presented.